http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019537549-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 |
| filingDate | 2018-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2019537549-A |
| titleOfInvention | Method for preparing avibactam intermediate |
| abstract | A method for preparing the avibactam intermediate, specifically ({[(2S, 5R) -2-albamoyl-7-oxo-1,6-diazabicyclo [3.2.1] octan-6-yl] oxy} sulfonyl) The present invention relates to a method for preparing tetrabutylammonium salt (II). Starting from 5R-benzyloxyaminopiperidine-2S-formate oxalate (III), the compound of formula V is prepared by amidation reaction with the aminated compound of formula IV, and the obtained compound V is converted to a carbonylation reagent. To give a compound of formula VI, benzyl or substituted benzyl is removed by catalytic hydrogenolysis, sulfated with a sulfur trioxide complex, and tetrabutylammonium chloride to give the final product (II). The process according to the invention is easy to control the reaction conditions, high in operability, simple in process, low in cost, low in by-products, highly economical in the reacting atoms and high in purity of the product (II) obtained. And the yield is high. [Selection diagram] None |
| priorityDate | 2017-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 145.