| abstract |
Disclosed are compounds of formulas I, II, and III, and pharmaceutically acceptable salts thereof, which are inhibitors of kallikrein. Pharmaceutical compositions comprising such compounds and methods comprising the use of the present compounds and compositions in the treatment and prevention of acquired or hereditary angioedema or other diseases and conditions characterized by abnormal kallikrein activity Also provide. (I) (II) (III) [Chemical 1] |