| abstract |
The present invention relates to a polypeptide comprising an extracellular ActRIIa variant. In some embodiments, a polypeptide of the invention comprises an extracellular ActRIIa variant fused to an Fc domain monomer or moiety. The present invention also provides bone damage, eg, primary osteoporosis, secondary osteoporosis, osteopenia, marble bone disease, fracture, bone cancer or cancer metastasis related bone loss, Paget's disease, renal osteodystrophy, treatment related Use these polypeptides to treat diseases and conditions that include bone loss, diet-related bone loss, bone loss related to obesity treatment, low-gravity-related bone loss, or immobility-related bone loss It relates to pharmaceutical compositions and methods. |