| abstract |
Provided are compounds having the structure of the following formula I, wherein R, R 1 , R 2 , R 3a and R 3b are as defined herein. Also provided are pharmaceutical compositions containing such compounds and methods relating to their manufacture and use. The present disclosure is generally directed to compounds that function as agonists of the chemokine receptor CXCR3, and compositions containing them, and methods for their preparation and use. In one embodiment, a pharmaceutical composition comprising a compound of formula I together with at least one pharmaceutically acceptable carrier, diluent or excipient is provided. |