http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019529468-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-03 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 |
| filingDate | 2017-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2019529468-A |
| titleOfInvention | Chroman, isochroman and dihydroisobenzofuran derivatives, compositions and their use as mGluR2 negative allosteric modulators |
| abstract | The present invention provides certain substituted chroman, isochroman, and dihydroisobenzofuran compounds of formula (I) or pharmaceutically acceptable salts thereof [ring A is (II), (III), (IV) and (V) is a moiety selected from ring B, n, R 1 , R 2 , R 2A , R 3 and R 3A as defined herein. ]I will provide a. The compounds of the present invention are useful as mGluR2 inhibitors or mGluR2 negative allosteric modulators (NAMs) by administering to a patient a therapeutically effective amount of a compound of the present invention or a pharmaceutically acceptable salt thereof. Useful in methods of treating patients for diseases or disorders involving mGluR2-NAM receptors, such as Alzheimer's disease, cognitive impairment, mild cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders Can be. The present invention relates to a pharmaceutical composition comprising a compound of the present invention or a pharmaceutically acceptable salt thereof (optionally in combination with one or more other active ingredients) and a pharmaceutically acceptable carrier, and so on. It also relates to the use of the compounds and pharmaceutical compositions of the invention in the treatment of various diseases. [Chemical 1] |
| priorityDate | 2016-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.