| abstract |
The present disclosure provides compounds represented by Formulas (I), (II), and (III). The provided compounds can bind to a protein kinase (eg, SIK) and modulate the activity of the protein kinase (eg, SIK, (eg, SIK1, SIK2, or SIK3)) in a subject or cell. May be useful in doing (eg, inhibiting). Provided compounds require this to treat or prevent diseases (eg, proliferative diseases, musculoskeletal diseases, genetic diseases, hematological diseases, neurological diseases, pain states, mental disorders, or metabolic disorders) It may be useful in performing on a subject. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve the compounds described herein. |