| abstract |
An antibody or antigen-binding portion thereof that binds to PSMA and includes a heavy chain variable domain comprising the sequence shown in SEQ ID NO: 33, wherein SEQ ID NO: 33 is EVQLVQSGX 9 EX 11 KKPGASVKV SCKX 24 SGYTFT EYTIHWVX 38 QA X 41 GKGLEWIGN INPNX 55 GGTTY NOKFEDRX 68 TX 70 TVDKSTSTAY MELSSLRSED TAVYYCAAGW NFDYWGOGTT VTVSS ( in the sequence, X 9 is a or P, X 11 is V or L, X 24 is a or T, X 38 is R or K X 41 is P or H, X 55 is N or Q, X 68 is V or A, and X 70 is I or L), according to which the heavy chain variable domain is An antibody or antigen-binding portion thereof comprising 3 or fewer amino acid sequence modifications between positions 1 to 30, 36 to 49, 67 to 98, and 105 to 115 of SEQ ID NO: 33. The invention also provides compounds, such as conjugates, comprising the antibody or antigen binding portion thereof, as well as their use in the treatment or diagnosis of diseases, particularly cancer, particularly prostate cancer. |