abstract |
The present invention relates to compositions and methods useful for symptomatic and disease modifying treatments and therapies. A compound of formula I (I), or an enantiomer thereof, a metabolite thereof, a derivative thereof, a deuterated derivative thereof, a halogenated derivative thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof, N-oxides, or combinations thereof, methods and intermediates for their preparation, compositions thereof, and uses thereof are provided. Compounds of formula I and compounds of formula II: (IIa) (IIb), or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, A pharmaceutical composition comprising an N-oxide, or a combination thereof. A pharmacokinetic effect beneficial to DEX, including improving the efficacy of DEX, including co-administration of a compound of formula I or SARPO and a compound of formula II or DEX to a subject in need thereof Compositions and methods for providing, as well as dosage forms, drug delivery systems, and therapeutic methods. [Selection] Figure 4 |