| abstract |
Compounds and compounds wherein the drug unit is linked to the targeting ligand unit via a self-stabilizing linker unit, from which the drug compound or active drug moiety is released at the target site of action; Compounds and composites are disclosed. Also disclosed are methods for treating diseases characterized by target abnormal cells, such as cancer or autoimmune diseases, using the compounds and compositions of the invention. Ligand-drug conjugates can provide tumor or cancer drug targeting specific for conjugation and thus reduce the overall toxicity of the drug. |