| abstract |
The present invention relates to a mutant immunoglobulin-binding protein having improved alkali tolerance, and more particularly, in a domain A of protein A of Staphylococcus or a functional variant thereof, an amino acid at a specific position is mutated and the parent The present invention relates to immunoglobulin binding proteins that exhibit improved chemical stability at alkaline pH values compared to molecules. INDUSTRIAL APPLICABILITY The present invention can provide an immunoglobulin-binding protein ligand and matrix for antibody purification that have improved alkali resistance and improved stability against a large number of alkali washes. |