| abstract |
The present invention provides (i) a first complement regulatory protein repeat (CCP) -containing domain that is a convertase decay-accelerating domain for classical and alternative pathway convertases of complement activation, (ii) a host cell recognition domain And (iii) a multidomain polypeptide comprising a second CCP-containing domain having cofactor activity. The present invention further relates to a polynucleotide encoding said multidomain polypeptide, a vector comprising said polynucleotide, and a host cell comprising said polynucleotide and / or said vector. Furthermore, the present invention relates to a multi-domain polypeptide for use in medicine and for treating and / or preventing diseases having inappropriate complement activation and / or inappropriate complement activation as a symptom. , Polypeptides and vectors. The present invention further relates to methods and uses relating to multidomain polypeptides, polypeptides, and vectors. [Selection figure] None |