abstract |
The present disclosure provides a T cell regulatory multimeric polypeptide comprising two different immunoregulatory polypeptides, at least one of which is a mutant immunoregulatory polypeptide. The present disclosure provides a nucleic acid comprising a nucleotide sequence encoding a T cell regulatory multimeric polypeptide and a host cell comprising the nucleic acid. The present disclosure provides a method of modulating the activity of a T cell, the method comprising contacting the T cell with a T cell modulating multimeric polypeptide of the present disclosure. |