| abstract |
The present invention is directed to substituted piperidine derivatives. Specifically, the present invention relates to a compound according to formula IIII: [Chemical formula 1] (Wherein, A, B, X, Y, L 1 , L 2 , L 3 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 9 , z 2 , z 4 , z 5 , And z 6 are as defined herein) And their salts. The compounds of the present invention are inhibitors of the ATF4 pathway and are associated with cancer, precancerous syndrome and activated unfolded protein response pathways such as Alzheimer's disease, spinal cord injury, traumatic brain. Injury, ischemic stroke, stroke, diabetes, Parkinson's disease, Huntington's disease, Creutzfeldt-Jakob disease and related prion disease, progressive supranuclear palsy, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, inflammation, fibers Disease, chronic and acute disease of liver, chronic and acute disease of lung, chronic and acute disease of kidney, chronic traumatic encephalopathy (CTE), neurodegeneration, dementia, cognitive disorder, atherosclerosis, eye disease, arrhythmia , In organ transplantation, and in the delivery of organs for transplantation. Thus, the present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treating disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. |