| abstract |
A method is disclosed for inhibiting heart valve stenosis, occlusion and / or calcification after implantation in a walled vessel. In one aspect, the method comprises providing a living heart valve mounted on a resilient stent; treating the living heart valve with a tissue fixative; one or more of the stent and the living valve. Coating with a coating composition comprising a therapeutic agent; implanting the biological valve into the vessel at the site of the affected native valve; eluting the coating composition from the biological valve; i) Stem cells to the living heart valve by activating nitric oxide production in the circulating stem cells, (ii) in the endothelial cell lining covering the living heart valve tissue, or (iii) both Inhibit the narrowing, occlusion and / or calcification of the living heart valve by preventing adhesion of the heart valve outside or near the living heart valve) It encompasses Rukoto. |