abstract |
A core composition comprising compound (I) and / or a pharmaceutically acceptable salt thereof, and a subcoating layer for coating the core composition, wherein the subcoating layer comprises polyvinyl alcohol and / or hydroxypropyl methylcellulose And an enteric coating layer encapsulating the subcoating layer and the core composition, wherein the enteric coating layer comprises at least one polymer selected from acrylic / methacrylic / ethacrylic acid homopolymers and copolymers thereof, a cellulose derivative, and polyvinylpyrrolidone A modified release formulation, such as a solid oral dosage form, comprising a soluble coating layer, and a method of administering a Breton-type tyrosine kinase (BTK) inhibitor using this formulation. |