| abstract |
A multi-arm, water-soluble polymer-modified targeted drug conjugate, wherein the drug conjugate has a structure as shown in structural formula (III). (III) (Wherein R is an organic center, POLY is a polymer, L is a multivalent linker, T is a target molecule, D is a camptothecin-based drug, and q is any integer from 3 to 8) is there.) The drug conjugate can improve the poor water solubility, high toxicity and low bioavailability of camptothecin drugs. |