| abstract |
The present invention relates to compounds of formula I or formula III, or pharmaceutically acceptable esters, amides, solvates or salts thereof, or salts of such esters or amides, or solvates of such esters, amides or salts . In the formula, the definitions of R 1 to R 13 and L 1 to L 4 are as described in the specification, and in the formula, R 14 is a peptide. A compound of Formula I is covalently linked to a peptide via a linker to prepare a compound of Formula III, thereby extending the half life of the therapeutic compound. The invention also relates to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases. |