| abstract |
The present disclosure provides methods and systems for identifying and / or treating subjects with cancer, such as squamous cell carcinoma, which are more likely to respond to treatment with an ERK inhibitor. The disclosure is a method of treating a subject having squamous cell carcinoma, the method comprising: (a) screening the subject for the presence or absence of a genetic signature indicative of sensitivity to an ERK inhibitor; (b) the gene Administering an ERK inhibitor to the subject if it is determined that a signature is present. |