abstract |
The present invention is a nucleic acid for the controlled expression of a nucleic acid encoding an apoptosis promoting protein in an individual, A regulatory polynucleotide comprising a minimal promoter and at least one AARE (amino acid response element) nucleic acid, wherein said regulatory polynucleotide is activated in the individual in response to the intake of a diet lacking at least one essential amino acid And a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the above-mentioned regulatory polynucleotide, The above nucleic acids. 【Selection chart】 None |