| abstract |
The present invention is a recombinant oncolytic virus, comprising VSV in which the glycoprotein (G protein) of Vesicular stomatitis virus (VSV) has been deleted, and a modified fusion protein of Newcastle disease virus (NDV) (NDV) The invention relates to a recombinant oncolytic virus, which comprises the F protein) and the hemagglutinin neuraminidase (HN) protein of NDV. The invention further relates to a nucleic acid encoding a recombinant oncolytic virus, and a vector comprising said nucleic acid. The invention further relates to a pharmaceutical composition comprising the rVSV of the invention, the above nucleic acid, or the above vector, and further to the use as a gene delivery tool and / or for tumor detection. The invention further relates to recombinant oncolytic vesicular stomatitis virus (VSV) for use in medicine, in particular for the diagnosis, prevention and / or treatment of cancer. |