| abstract |
The present invention provides, inter alia, multimer-encoding nucleic acids which exhibit excellent stability for in vivo and in vitro use. In some embodiments, a multimer-encoding nucleic acid (MCNA) comprises two or more encoding polynucleotides linked via the 3 'end, and the compound of the multimer-encoding nucleic acid has two or more 5'-ends. To include The present invention is, for example, a multimer-encoding nucleic acid (MCNA), comprising two or more encoding polynucleotides linked via the 3 'end, wherein the compound of the multimer-encoding nucleic acid is 5' or more 5 '. The multimer-encoding nucleic acid is provided, which comprises an end. [Selected figure] Figure 1 |