| abstract |
The present invention provides a secreted protein sDSS1 of higher primates. The sDSS1 protein can be conjugated with the oxidized protein to form a polymer under non-enzymatic conditions, or conjugated with an Aβ polypeptide to reduce the formation of Aβ oligomers. It can also block the cytotoxicity caused by oxidized proteins, Aβ oligomers, amylin oligomers and glycosylated proteins. The protein is used for the prevention and treatment of diseases caused by excess production or accumulation of oxidized protein, glycated protein, accumulation of Aβ protein, accumulation of amylin protein, or other pathogenic proteins having similar properties. obtain. |