| abstract |
Disclosed herein are a composition for promoting skin cell differentiation and a method of screening for a skin cell differentiation promoting substance. The composition for promoting skin cell differentiation according to the present invention suppresses the expression or activity of JAB-1, and as a result, suppresses migration of soriacin into cell nuclei and effectively promotes skin cell differentiation. it can. Therefore, the composition is effective for skin moisturizing, skin barrier function strengthening, or atopic relief treatment. In addition, according to the screening method of a skin cell differentiation promoting substance according to one aspect, keratinocyte differentiation promotion is facilitated simply, rapidly and efficiently by treating keratinocytes with a test substance and confirming the relative expression degree of JAB-1. Substances can be screened. [Selected figure] Figure 4 |