| abstract |
The subject matter disclosed herein provides antigen binding proteins (eg, chimeric antigen receptors) and antibodies or antigen binding portions thereof that bind to Foxp3 peptide / MHC molecule complexes. Such antibodies, their fusion proteins and conjugates are useful for the inhibition of regulatory T cells and for the treatment of cancer. The subject matter disclosed herein identifies and characterizes antigen binding proteins, such as antibodies and chimeric antigen receptors that can target the Foxp3 transcription factor. |