| abstract |
The present invention provides herpesviruses, such as EBV, which lack at least one viral miRNA. Such herpesviruses, which lack at least one viral miRNA, advantageously can not package their genome into a capsid, whereby their herpesvirus genome, or the protein portion of the HVLP HVLPs are generated that are substantially free of the encoding nucleic acid molecule and the viral miRNA. Such HVLPs can be used as a vaccine. |