| abstract |
The present invention provides methods for preparing expanded biological specimens suitable for microscopic analysis. Swelling the biological sample is accomplished by attaching important biomolecules to the polymer network, eg, anchoring, swelling or swelling the polymer network, and thereby pulling away the biomolecules as described further below. It can be done. When the biomolecule is tethered to the polymer network, the isotropic expansion of the polymer network retains the spatial orientation of the biomolecule, resulting in an expanded or expanded biological specimen. |