abstract |
One or an increased content compared to the content of N-glycan units expressed in Chinese hamster ovary (CHO) cells and having one or two mannose-6-phosphate residues of alglucosidase alpha A recombinant acid alpha-glucosidase comprising N-glycan units having two mannose-6-phosphate residues; at least one buffer selected from the group consisting of citrate, phosphate and combinations thereof; And a pharmaceutical formulation comprising at least one excipient selected from the group consisting of mannitol, polysorbate 80, and combinations thereof, wherein the pharmaceutical formulation has a pH of about 5.0 to about 7.0 Provided. Methods for treating Pompe disease using these pharmaceutical formulations are also provided. [Selection] Figure 6 |