| abstract |
The present invention is for the synthesis of (2E, 4E, 6Z, 8E) -8- (3,4-dihydronaphthalene-1 (2H) -ylidene) -3,7-dimethylocta-2,4,6-trienoic acid. Relates to the new method. In particular, the present invention relates to several improvements in several individual steps of a multi-step synthesis scheme. In a second aspect, the present invention is a method for the synthesis of MRZ-20321 in a solvent selected from benzotrifluoride and 1,3-bis (trifluoromethyl) benzene, in particular in benzotrifluoride. To a method comprising the step of synthesizing 2 (as a mixture of E / Z isomers) by performing a bromination of 1. |