| abstract |
The present invention provides a method for purifying complexed 227Th from a mixture comprising complexed 227Th and 223Ra (complexed or in solution), the method comprising i) complexed Preparing a first solution containing a mixture of 227Th ions and 223Ra ions in a first aqueous buffer; ii) loading the first solution onto a separation material; iii) complexed 227Th Elution from the separation material, thereby producing a second solution comprising 227Th complexed; iv) optionally rinsing the separation material with a first aqueous wash medium. The present invention further provides purified 227Th solutions, pharmaceutical formulations and their use in the treatment of diseases such as cancer, and kits for producing such products. |