| abstract |
The present disclosure relates to formulations of peptide agents that bind to dengue virus, such as antibodies and antigen-binding fragments thereof, and methods of their use. The disclosure provides, at least in part, a formulation of an antibody molecule that binds to a dengue virus, eg, dengue virus E protein, and includes the functional and structural properties disclosed herein. In some embodiments, the antibody molecule binds to the “A” beta-strand of EDIII (E protein DIII domain). In some embodiments, the antibody molecule binds to and / or binds to at least 1, 2, 3 or 4 dengue virus serotypes, eg, DV-1, DV-2, DV-3 and DV-4. Neutralize. |