| abstract |
Antibodies that bind to connexin 43 hemichannels and inhibit or activate channel opening are provided. In certain embodiments, a method for detecting or treating cancer with an antibody that activates a Cx43 channel opening is also provided. Similarly, methods for treating inflammatory diseases (eg, osteoarthritis) and nerve injury (eg, spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided. [Selection] Figure 1 |