| abstract |
The present invention provides an antibody that specifically binds to EGFRvIII (epidermal growth factor receptor variant III). The invention further provides bispecific antibodies that bind to EGFRvIII and another antigen (eg, CD3), as well as antibody conjugates (eg, antibody-drug-conjugates). The invention further relates to nucleic acids encoding the antibodies as well as methods of obtaining such antibodies (monospecific and bispecific) and antibody conjugates. The invention further relates to treatment methods using these antibodies and antibody conjugates for the treatment of EGFRvIII related disease states, including cancers such as glioblastoma. |