| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0457
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0829
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0887
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0406
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0487
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2200-0621
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-086 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F04B23-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F04B23-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F04B19-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F04B43-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F04B43-043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-50273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502738
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N35-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2017-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2019-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2019505214-A |
| titleOfInvention |
Modular organ microphysiological system with integrated pumping, leveling and sensing |
| abstract |
A fluid multiwell bioreactor is provided as a microphysiological platform for in vitro investigation of multi-organ crosstalk over a long period of at least weeks and months. The disclosed platform includes onboard pumping for pneumatically driven fluid flow, a redesigned outflow path for self-leveling from the source to the sink, a non-contact built-in fluid level sensing device, a fluid flow profile and Characterized by one or more improvements over existing bioreactors, including precise control over partitioning, and simple reconfiguration such as daisy chaining and multilayer stacking. The platform supports the cultivation of multiple organs in a suitable microphysiological interaction system for a wide range of biomedical applications including systemic toxicity studies as well as physiologically based pharmacokinetic and pharmacodynamic predictions. A process for making the disclosed bioreactor is also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7092438-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023021591-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021136995-A |
| priorityDate |
2016-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |