| abstract |
The present disclosure generally uses a mechanical and / or biochemical dissociation method to homogenize an intact sample or a large portion thereof, such as a clinical sample, eg, a tumor (whole or part), lymph It relates to the preparation of representative samples from nodes, metastases, cysts, polyps, or combinations or parts thereof. The resulting homogenate provides the ability to obtain accurate representative samples despite the spatial heterogeneity within the sample, increased detection likelihood of low-incidence subclones, and is used in various diagnostic assays as well as It is suitable for the production of therapeutic agents, in particular “individualized” anti-tumor vaccines or immune cell based therapies. [Selection] Figure 2A |