| abstract |
The present invention relates to the diagnosis and treatment of diseases including inflammatory disorders, proliferative disorders and autoimmune diseases. The present invention provides antibody molecules that bind to the D domain of i) lysozyme, ii) neutrophil elastase, iii) tissue metalloprotease inhibitor-1 (TIMP-1) or iv) tenascin-C, and uses thereof Including. The present invention relates to v) the IIICS isoform of fibronectin, vi) fibronectin extra domain-B (ED-B), vii) matrix metalloproteinase 3 (MMP3) in the diagnosis and treatment of inflammatory disorders such as inflammatory bowel disease. Or viii) also relates to the use of antibody molecules that bind to the A1 domain of tenascin-C. [Selection figure] None |