| abstract |
A charged linker is provided for linking a drug to a cell binding agent (eg, an antibody). The cell binding agent-drug conjugate of (II). [CB: cell binding agent; D: drug linked to CB by peptide or the like; R 1-10 : H etc .; l, m, n: integers from 0 to 4; A: phenyl etc .; : (OCH 2 CH 2 ) p polyethyleneoxy units; p: 0 or an integer from 2 to about 1000; Y: carbonyl] [Selection diagram] Fig. 1 |