| abstract |
The present invention provides compositions and methods that may be useful for enhancing the biological, pharmaceutical, safety and / or therapeutic properties of a bioactive protein. The present invention relates to a composition comprising a biologically active protein linked to an extended recombinant polypeptide (XTEN), an isolated nucleic acid encoding the composition and vectors and host cells containing the same, and glucose-related diseases. The use of such compositions in the treatment of metabolic disorders, coagulation disorders, and growth hormone-related disorders and conditions. In one aspect, the invention provides a composition of an extended recombinant polypeptide (XTEN), which, when linked to a bioactive protein, enhances the pharmacokinetic properties of the resulting fusion protein; And / or increase the solubility and stability of the resulting fusion protein, while enhancing the overall biological and / or therapeutic activity of the bioactive protein. [Selection figure] None |