abstract |
Disclosed is a farnesoid X receptor modulator. The present application relates to a compound of formula I as described herein: Or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. The present invention relates generally to FXR modulators and methods of making and using such compounds. There remains a need for further selective FXR modulators suitable for drug development, such as compounds that are non-selective for other nuclear receptors and / or do not significantly activate bile acid GPCR TGR5. [Selection figure] None |