| abstract |
Disclosed is a fusion polypeptide comprising a ligand that is modified by circulating substitution that functions as an agonist, superagonist, or antagonist of a signal transduction pathway, and a method for using the same. A fusion polypeptide comprising an amino acid sequence having a specific amino acid sequence or having an amino acid sequence sequence at an amino acid level of at least 85% relative to the IL- A fusion polypeptide that selectively stimulates 2Rβγ. [Selection figure] None |