| abstract |
The present invention provides a novel preparation that inhibits precipitation of an immunogenic composition. S. pneumoniae serotype 4 polysaccharide conjugated to CRM197 polypeptide, S. pneumoniae serotype 6B polysaccharide conjugated to CRM197 polypeptide, S. pneumoniae serotype 9V conjugated to CRM197 polypeptide S. pneumoniae serotype 14 polysaccharide conjugated with CRM197 polypeptide, S. pneumoniae serotype 18C polysaccharide conjugated with CRM197 polypeptide, S. pneumoniae serotype 19F polysaccharide conjugated with CRM197 polypeptide, etc. A formulation that stabilizes a polysaccharide-protein conjugate of: (i) a pH buffered salt solution, wherein the buffer has a pKa of about 3.5 to about 7.5, (ii) a surfactant Agents and (ii ) One or more polysaccharide - formulation comprising the protein conjugate. [Selection figure] None |