| abstract |
PROBLEM TO BE SOLVED: To provide a composition for preventing or treating heart failure in a mammalian subject, reducing risk factors associated with heart failure, and / or reducing the likelihood of heart failure or the severity of heart failure. There is a need to reduce the level of one or more of C-reactive protein, reactive oxygen species, interleukin 6, TNFα, cardiac troponin I, NT-pro BNP, MLCL AT1 expression, and ALCAT1 expression. And / or in mammalian subjects in need of increasing Taz1 expression, of C-reactive protein, reactive oxygen species, interleukin 6, TNFα, cardiac troponin I, NT-pro BNP, MLCL AT1 expression, and ALCAT1 expression A therapeutically effective amount of the peptide D-Arg-2 ′, 6′-Dmt-Lys-Phe-NH 2 or pharmaceutically thereof for decreasing one or more levels and / or increasing Taz1 expression A composition comprising an acceptable salt. [Selection] Figure 1 |