| abstract |
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition having improved dissolution properties of cinacalcet hydrochloride as an active ingredient from a tablet. The active ingredient is cinacalcet hydrochloride, the excipient is (a) one or more selected from lactose hydrate, crystalline cellulose, or D-mannitol as a diluent, and (b) a disintegrant. One or more selected from crospovidone, carmellose, carmellose calcium, croscarmellose sodium, low-substituted hydroxypropylcellulose, or partially pregelatinized starch, (c) hydroxypropylcellulose as a binder, or polyvinyl alcohol polyethylene Active ingredient containing no granule / graft copolymer or binder, (d) one or more selected from lubricant magnesium stearate or talc, granulated and compression molded It is a pharmaceutical composition with improved dissolution. [Selection] Figure 1 |