abstract |
An improvement in dry powder technology is provided. A method of manufacturing one or more receptacles having a dry powder suitable for respiration disposed therein, the method comprising: Placing the respirable dry powder in a plurality of the receptacles at a target fill weight and a rate of about one receptacle every 4 seconds or less to produce a filled receptacle, wherein the filled At least 80% of the receptacle includes the respirable dry powder within 85% to 115% of the target fill weight, Including The respirable dry powder comprises respirable dry particles, wherein the respirable dry particles have a volume geometric median diameter (VMGD) of about 10 micrometers or less and a tap of at least about 0.45 g / cubic centimeter. A method comprising one or more therapeutic agents having a density and providing at least about 25% of the total mass of the sodium salt and the contents disposed within the sealed receptacle. [Selection figure] None |