http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019170225-A

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filingDate 2018-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d84428e91ea2f9e54ceaef41cdfde80
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publicationDate 2019-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2019170225-A
titleOfInvention Endoribonuclease and its inhibitors
abstract Disclosed is an endoribonuclease and an inhibitor that suppresses the activity by binding. An endoribonuclease represented by an amino acid sequence consisting of a specific sequence or an amino acid sequence having at least one of deletion, addition, insertion or substitution of 0 to 10 amino acid residues in the sequence. The 5′-UGG-3 ′ sequence contained in the RNA is recognized, and the phosphodiester bond on the 3 ′ side of the first base of the sequence is hydrolyzed. When this endoribonuclease is allowed to act on single-stranded RNA, a predetermined sequence of RNA is recognized and decomposed. However, when an inhibitor is bound to this endoribonuclease, the above-described degradation is stopped. [Selection figure] None
priorityDate 2018-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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