| abstract |
The present invention provides immunosuppressive Tat derivative polypeptides, compounds, and methods using such polypeptides and compounds for treating autoimmune diseases, inflammation-related diseases, and / or neurodegenerative diseases. An immunosuppressive human immunodeficiency virus (HIV), a SIV immunosuppressive transcription transactivator (Tat) protein, a transcription factor (TF) domain comprising a sequence derived from hairless or artificial immunosuppressive sequences, a lentivirus An immunosuppressive transcriptional transactivator (Tat) comprising an amino acid sequence comprising, in the order shown, a domain that is a cysteine-rich region derived from a Tat or defensin molecule and a domain that is a C-terminal region derived from a lentiviral Tat protein. Derivative polypeptide. [Selection figure] None |