Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8603ee14f13e9c3d3f6d5858bf4f3bf |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-193 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1816 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
filingDate |
2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_288d1012f6456c144b869bad6502db15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4842ccece5c28a7db1fee06aa48000b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69869a986a2713b47539858d8e52cd64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7704bb66ba28a8bf417b45d4cb3fae6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7dce7890603626b9e9e3aa972627d54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_581cc7c4f9a89b16b594741d3be1bdca |
publicationDate |
2019-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2019163258-A |
titleOfInvention |
Conjugate of physiologically active polypeptide monomer and immunoglobulin Fc fragment with reduced receptor-mediated clearance and method for producing the same |
abstract |
Provided is a conjugate having an increased half-life in blood by binding an immunoglobulin Fc fragment to a physiologically active polypeptide. A composition comprising a conjugate in which a physiologically active polypeptide is linked to an immunoglobulin Fc fragment, wherein the composition comprises one molecule of the physiologically active polypeptide linked to one immunoglobulin Fc fragment. And a multimeric conjugate in which two or more molecules of the same physiologically active polypeptide are linked to one immunoglobulin Fc fragment. A long-acting pharmaceutical composition wherein the molar ratio of monomeric conjugate to multimeric conjugate in the composition is 19 or greater. [Selection] Figure 1 |
priorityDate |
2013-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |