| abstract |
A composition for treating celiac sprue is provided. A polypeptide comprising an amino acid sequence at least 75% identical to a protease having a specific amino acid sequence designed from the enzyme kumamoricin-As, comprising: (a) degrading a PQPQLP peptide at pH 4; ) Residue 278 is Ser, residue 78 is Glu, residue 82 is Asp; and (c) residues 73, 102, 103, 104, 130, 165, 168, 169, 172 and 179 A composition comprising a protease comprising an amino acid change compared to post-processed kumamoricin-As at one or more residues selected from the group consisting of: [Selection] Figure 3 |