| abstract |
An object of the present invention is to provide a composition that avoids local concentration of an active ingredient in the digestive tract. An active substance selected from one or more fumaric acid esters selected from dialkyl esters of fumaric acid or monoalkyl esters of fumaric acid, or pharmaceutically acceptable salts thereof, and hydroxypropylcellulose, hydroxy A controlled release pharmaceutical composition comprising one or more hydrophilic excipients selected from ethyl starch and hydroxypropylmethylcellulose. [Selection figure] None |