| abstract |
A method for treating a disease or disorder using an antigen-binding fragment, a pharmaceutical composition containing the antigen-binding fragment, and a production method are provided. An antigen-binding protein and a fragment thereof that specifically bind to B cell mature antigen (BCMA), particularly human BCMA (hBCMA), and inhibit the binding of BAFF and APRIL to BCMA receptor. Pharmaceutical compositions, screening and medical treatment methods. Use in the treatment of human patients suffering from B-cell lymphoma, such as multiple myeloma (MM) or chronic lymphocytic leukemia (CLL). [Selection] Figure 1 |