abstract |
An anti-blood dendritic cell antigen 2 (BDCA2) antibody and use thereof are provided. An isolated nucleic acid encoding an antibody comprising a specific amino acid sequence portion and binding to BDCA2. In human subjects, downregulates CD32a expression on the surface of plasmacytoid dendritic cells, inhibits stimulation of plasmacytoid dendritic cells by immune complexes or downregulates expression of CD62L on the surface of plasmacytoid dendritic cells A composition comprising the antibody for modulation. A method for detecting the presence of plasmacytoid dendritic cells in an isolated tissue comprising contacting the tissue with the antibody. [Selection] Figure 33 |